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Prescription Medications Doctors may prescribe medications for short-term or severe insomnia, including: Non-benzodiazepine hypnotics (e.g., zolpidem, zaleplon, eszopiclone) Benzodiazepines (e.g., temazepam, triazolam generally for short-term use only) Melatonin receptor agonists (e.g., ramelteon) Orexin receptor antagonists (e.g., suvorexant, lemborexant) Low-dose antidepressants with sedative effects (e.g., doxepin, trazodone) Treatment of Underlying Conditions Management of medical or psychiatric issues (e.g., sleep apnea, depression, anxiety, chronic pain, hormonal issues) that may interfere with sleep strategies may improve sleep

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